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The stress of childhood puts a profound effect on the brain: study

by Sandhya Hirani
June 10, 2025
The stress of childhood puts a profound effect on the brain: study

New Delhi, 10 June (IANS). According to a new study, stress and difficult experiences in childhood can have a profound effect on mental health. Childhood trauma may have a permanent effect on the brain. Even it can become the cause of mental disorders.

This research suggests that childhood difficulties bring permanent changes in brain structure and immunity, which increases the risk of depression, bipolar disorder and other mental illnesses.

“The immune system is not just fighting infection, but also plays an important role in shaping our mental health,” said Sara Poleti, senior researcher at IRCCS Ospedale San Refel, Italy’s Milan.

He said that childhood stress changes this system, which increases the risk of mental illnesses after decades. Research has identified the special inflammatory indicators (inflammatory markers) that are associated with childhood stress.

The research published in the journal ‘Brain Medicine’ gives attention to the use of immunomodulatory agent (Interlucin 2) for the treatment of mood disorder (other mental disorders, including depression).

According to the World Health Organization, mood disorder is the major cause of disability, disease and death worldwide. In future, the rate of depression situation can be around 12 percent and up to 2 percent of bipolar disorder.

Research found that the immune system disturbances in the mood disorder, especially the inflammatory response system plays an important role. This disturbance can become a major cause of these disorders. Research found that inflammatory indicators (inflammatory markers), which are associated with childhood stress, can form the basis for developing new and better treatment of mental illnesses in future. These indicators will help doctors understand how to treat the disease.

Sara Polati says that she wants to understand the relationship between the immune system and the environment. Their goal is to develop such prevention strategies that reduce the risk of mental illnesses especially in stressed childhood.

This research is a major step towards understanding psychiatric care and focusing on prevention.

-IANS

MT/KR

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