In severe cases of corona infection, there is swelling and burning in the body of many patients. Now the veil has been exposed for its reasons. Immunologists from Boston Children’s Hospital in the US have claimed in research that there is inflammation and irritation when the corona virus affects immune cells called monocytes and macrophages.
New research published on Wednesday in the journal ‘Nature’ has helped to understand how this immune overreaction occurs in patients with COVID-19. It also suggests that the SARS-CoV-2 virus can infect certain immune cells called monocytes and macrophages.
Frontline cells infected:
Monocytes and macrophages are white blood cells and act as frontline workers of the immune system. Their job is to find and destroy pathogens circulating in the blood and tissues.
However, this did not happen in the cases of SARS-CoV-2 virus. The virus emerged from the endosome and entered the body of the cell, where it began to copy itself.
Virus copying itself worrying: immunologist
Dr. Judith Lieberman, a pediatric immunologist at Boston Children’s Hospital, said it was always worrying for the virus to start copying itself in the body, but when it happened to these guard cells, it increased the risk.
Very difficult to stop
According to Dr. Lieberman, pyroptosis is a new phenomenon. It also occurs in other diseases such as pus, and when cells die from pyroptosis, they release a variety of inflammatory proteins, causing fever and inviting more immune cells to visit the site of infection. Is. This would have erupted like a cascade of distress signals, which are extremely difficult to stop.
spreads like fire:
Donna Farber, professor of microbiology and immunology at Columbia University, said that once the inflammation and inflammation starts, we have no way of treating it. It’s like a fire. It spreads and flares up and no firefighters have been able to control it.
Role of Antibodies:
Another piece of research indicates that there may be a way to stop this inflammation and irritation. This method is by monocytes and macrophages without ace-2 receptors, which are the gates the virus uses to infect other cells.
Another immune system helper causes the virus to enter these cells, yet Y-shaped antibodies take over the virus, trying to prevent it from taking over our cells.