New Delhi, December 4 (IANS). A study on Wednesday proved the possible link between poor sleep and metabolic dysfunction-associated steatotic liver disease (MASLD).
MASLD was previously known as non-alcoholic fatty liver disease. This is the most common liver disease. The disease affects 30 percent of adults and 7 to 14 percent of children and adolescents. The disease is projected to affect more than 55 percent of adults by 2040.
Previous studies have linked disruptions in the circadian clock and sleep cycle to the development of MASLD, but the new study from researchers at the University of Basel in Switzerland shows for the first time that patients with MASLD have different sleep-wake patterns than healthy people. Is.
In a paper published in the journal Frontiers in Network Physiology, the team showed that patients with MASLD woke up 55 percent more often during the night and stayed awake 113 percent longer after falling asleep, compared with healthy people. Patients with MASLD sleep more frequently and for longer periods of time during the day.
“Patients with MASLD have more frequently interrupted sleep at night, resulting in more frequent awakenings and longer periods of sleep,” said Dr. Sophia Schaefer, a postdoctoral researcher at the University of Basel.
The team included 46 adult women and men who had cirrhosis with either MASLD or MASH. These were then compared with 8 patients who did not have MASH-related liver cirrhosis. They were also compared with 16-year-old healthy volunteers of the same age.
Each study participant wore an ActiGraph wristband, which tracked motor activity (gross motor activity), light, physical activity and body temperature through a sensor. It was always worn.
The results showed that sleep patterns and quality measured by actigraph were equally affected in patients with MASH, MASH with cirrhosis, and non-MASH related cirrhosis.
Additionally, 32 percent of patients with MASLD reported experiencing sleep disturbances due to mental stress, compared to only 6 percent of healthy participants.
“The results showed that sleep disruption plays a role in the development of human MASLD,” said Dr. Sophia Schaefer.
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