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Only one dose of ‘Magic Mushroom’ will give relief from depression for five years, Researchers’ big claim in Research by Yale University

by Sandhya Hirani
June 25, 2025
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A new medical discovery for patients suffering from serious illness like cancer has brought a new ray of hope. A recently published scientific study claimed that the active compound found in ‘Magic Mushrooms’ (Magic Mushrooms) can play a revolutionary role in relieving the psilocybin, depression and anxiety – and that too in just one dose. This research found that when Salilisabin was given with therapy, it not only provided immediate mental relief to the patients, but its effects remained for more than two years. Scientists believe that this treatment can become a new milestone to treat mental health problems in cancer patients in future.

In which journal was a study published?

The study has been published in the Peer-review magazine ‘Cancer’ of America’s prestigious American Cancer Society, which was released by Wiley Online. According to researchers, depression and anxiety are common problems in people suffering from fatal disease like cancer, whose treatment is often incomplete from traditional drugs and psychiatric processes.

Major things of study

The study was presented as a Phase-2 trial, which included 28 cancer patients, who were struggling with severe depression.

The process of research was as follows:

Patients were given just one dose of 25 mg of salilisabin.

He was given therapy by trained psychologists before, during and after this medicine.

Two years later, when these patients were followed, the surprising results came out.

Impressive results

✅ 15 patients (53.6%) saw a public reduction in depression.

✅ 14 patients (50%) have a complete end of depression as well as symptoms.

✅ 12 patients (42.9%) also saw long -term relief in anxiety.

These results are not only impressive, but it shows that cylosybin -like psychidelic substances can have a deep and longer effect on mental health, even when used only once.

What are the major researchers saying?

Dr. Manish Aggarwal, the lead author of this study, said:

“Positive effects have been seen for two years by giving saliliabin and psychological support to cancer patients suffering from depression. Now we are taking this research further, so that it can be seen whether more than half of the patients can get full relief if this process is repeated.”

He also said that if the same results are repeated in randomized and double-blind trials, then this medical system can become a standard treatment for cancer patients.

What is the plan next?

Researchers have now started the process of a large number of patients, more than one doses, and double-blind controlled trial, moving in this direction.

Its purpose is to ensure that:

Does this treatment work effectively in all cancer patients?

Can more than two or more doses be relieved?

Can this treatment be applied safely and long term?

Future of psychidelic treatment

This study has challenged all the beliefs that believed that only regular medicines could be effective in treating mental illnesses. Now the chances of using psychidelic substances (such as salilisabin, LSD, etc.) with therapy are increasing the possibilities of increasing mental health.

This therapy can be extremely useful for those patients:

Those who are unable to benefit from traditional antidepressants

Terminal or chronic diseases are under mental stress

Those who need quick but safe relief

What is SilioSibin?

Siloisibin is a natural compound found in mushrooms of some species of wild or cultivated. It is usually known as ‘Magic Mushroom’. This affects serotonin receptors in the brain and temporarily replaces the person’s ability to think, feel and understand. It is now being used for medical purposes under controlled and expert care. Overall, this study indicates a significant twist – where a one -time salilisabin dose can relieve mental health of cancer patients for years. If the same results are found in the upcoming trials, then it can prove to be a revolutionary change in the world of mental health treatment. In countries like India, where the number of cancer patients is continuously increasing and mental health resources are limited, these types of treatment can become a new hope – provided that its use from a scientific point of view gives proper legal and medical permission to its use.

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