New York, 8 June (IANS). Biomedical scientists have made a new discovery that found that a genetic change associated with Crohn’s disease can further increase iron deficiency and anemia (anemia) in the body. This problem is found to be common in those who suffer from inflammation related to inflammation, ie intestinal inflammation.
The study was conducted at the University of California, Rivaruside School of Medicine, USA. In this, scientists examined the serum samples of IBD patients and found that the genes whose body (protein tyrosin phosphate non-sipter type 2) has a special type of change (mutation) in the gene called Non-Rispter Type 2, their blood does not work properly.
This genetic change is found in about 14 to 16 percent of common people and 19 to 20 percent of IBD patients. Due to this change, the normal function of the gene stops or reduces very low.
IBD can affect not only the intestines but the entire body. The study published in the International Journal of Molecular Sciences said that anemia due to iron deficiency is most prevalent in these effects, which causes chronic fatigue and lack of quality of life, especially during the increase of disease.
Declane McCol, Professor of Biomedical Sciences in UCR, said, “This discovery helps us understand why some patients decrease the ability to absorb and control iron in the body due to genetic reasons. That is why some patients do not improve their condition even if they give iron pills.”
When researchers removed this PTPN2 gene in mice, they also got anemia and they could not take the iron properly from food. The reason for this was found that an essential protein absorbing iron in their intestinal cells was being formed in very small amounts.
Prior to the study, the author Hilmin Lee said, “The only means of iron in the body is food, so this discovery matters a lot.”
This research has also revealed that IBD patients who have this genetic change in their body are usually not able to take advantage despite taking iron medicine.
This study is an essential step towards better understanding diseases like IBD, which shows that nutritional problems can be more serious due to genetic reasons.
-IANS
AS/
