New Delhi, 12 April (IANS). American researchers have identified a new gene group through modern technology CRISPR Interfensions. This gene increases the risk of Parkinson’s disease.
More than 10 million people worldwide suffer from Parkinson’s disease. It is the second most common neurodynative disease after Alzheimer’s disease.
Researchers have been investigating for a long time why Parkinson’s development develops in some people with pathogenic variants? Whereas this does not happen in others with such variants. The prevailing principle suggested that additional genetic factors could also play a role.
The study published in the Science Journal identifies a new set of genes and cellular passages, which play a role in the risk of development of Parkinson’s disease.
Scientists at Northwestern University discovered the entire human genome using CRISPR interfensions technology.
They found that a group of 16 proteins called commanders together first play an unknown role in delivering specific proteins to the lysosome (a part of the cell that acts like a recycling center), which breaks up waste materials, chronic cell parts, and other unwanted substances.
“Our studies show that a combination of genetic factors plays a role in the appearance of diseases like Parkinson’s disease,” said Dr. Dimitri Cranek, Chairman of Devi Department of Neurology at the university and director of the Institute of Phoenburg Neuroscience,, which plays a role, meaning that such disorders will have to consider the medical targeting of several major routes.
Instead of studying thousands of patients, the team resorted to CRISPR.
“We used the genome-wide CRISPR intervention screen to calm each of the protein-coding human genes in cells and identified important people for PD pathogenesis to calm each of the protein-coding human genes in cells.”
By examining the genomes of two independent groups, scientists found that people suffering from Parkinson’s disease have more work-loss variants in people suffering from Parkinson’s disease than in commander genes.
“This shows that the work-loss variants in these genes increase the risk of Parkinson’s disease.”
-IANS
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