New Delhi, 26 June (IANS). Biological drugs or biologics improve the lives of severe asthma patients, but according to a new study, even after the use of these drugs, there are some immune cells that are inflammatory and do not end completely.
Researchers at the Carolinska Institute, Sweden said in a new study that even though biologic drugs used in the treatment of severe asthma may improve patients’ conditions, they do not completely eliminate some immune cells that cause inflammation in the blood.
This study is published in the scientific magazine ‘Allergy’. According to research, swelling in the airway may begin again when the treatment is stopped due to the presence of these cells.
Researchers analyzed blood samples of 40 severe asthma patients, taking biologics medications. These drugs, such as the mapolazumab and dupillamab, helped control the symptoms of patients, but surprisingly saw an increase in the number of immune cells that cause inflammation in the blood.
“Biologics does not completely eliminate the root of inflammation, showing the tissue immunology professor at the Karolinska Institute. It shows that treatment may continue to continue to control the disease.”
Research used high technology such as flow cytometry and single cell sequencing, detecting the properties and functions of immune cells.
Researcher Lorenz Varth said, “The cells that cause inflammation during treatment increased rather than decreasing. It explains why inflammation in the airway returns when treatment is reduced or closed.”
Biologics has been used in the treatment of severe asthma for the past decade. But, there is very little information about his prolonged effects.
Researchers say that it is important to understand the effects of prolonged use of these drugs. The research team is now planning to analyze the samples of patients who have been undergoing treatment for a long time. Also, they will examine the lung tissue to understand the effects on immune cells in the airway.
Researchers believe that this discovery will help develop more effective treatment in the future.
-IANS
MT/Ekde
