New York, 23 March (IANS). A team of scientists have discovered procedures that can help understand the abnormal function of immune cells. This imbalance can cause an inflammatory bowl disease called Crohn’s disease.
Crohn’s disease causes prolonged inflammation in the digestive system (gastrointestinal tract). Its symptoms include abdominal pain, diarrhea, weight phenomenon, anemia (anemia) and fatigue.
Our intestines contain white blood cells, which are called intraiphynestial lymphocytes (gamma delta IEL). These cells protect against infection and help protect the intestine. But in those who have Crohn’s disease, these gamma delta IELs often decrease.
Scientists at the University of Mount Sinai reported that this study first shows that gamma delta cells play a very important role in controlling inflammation. When the lower small intestine persists for a long time, these cells become weak.
“In earlier investigations, people with IBDs (intestinal inflammation) active in patients tissue (biopsy) were seen in the IEL cells,” said Associate Professor Caren Edelbum at Econy School of Medicine, Mount Sinai.
Now this new study, which has been published in the magazine of Science Immunology, shows that the number of these cells starts to decrease several weeks before Crohn’s disease develops.
Researchers say that deficiency of gamma delta IEL cells can be used as an indicator for re -having disease or understanding of treatment.
In addition, if such drugs are developed in the future that increase the functionality of these cells, it can be a new treatment for IBD patients and can help potential patients to protect against the disease.
-IANS
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