New Delhi, November 10 (IANS). To find out more about how humans age, a team of scientists has discovered how immunoglobulins affect the aging process.
The team from the Chinese Academy of Sciences (CAS) and BGI Research created high-precision spatial transcriptomic maps by analyzing millions of spatial spots in nine organs of male mice.
These maps showed more than 70 types of cells. This helped scientists understand the patterns of aging.
Research called gerontological geography (GG) highlights common aspects of tissue structural disruption and loss of cellular identity in the aging process.
Professor Liu Guanghui, one of the authors of the study published in the journal Cell, said: “This scenario is an important tool in characterizing the centers of aging in many organs and highlighting the accumulation of immunoglobulins as a key symptom and driver of aging. It’s a step.”
The discovery of systemic biomarkers and major causes of aging has long been a puzzle in the field of gerontology.
Researchers found that during aging, structural disturbances occur in the body’s tissues and cells. In addition, loss of cell identity reduces the functional capacity of organs and spatial structural damage may be the main cause of aging.
The team also identified senescence-sensitive spots (SSS), which are structural regions in various tissues that are more sensitive to the effects of aging.
They found that regions adjacent to the SSS have higher tissue structural entropy and greater loss of cellular identity, indicating that the SSS may be central to organ aging.
This study is the first to map the spatial transcriptome of pan-organ aging in mammals, revealing tissue structural dysregulation and loss of cellular identity as key hallmarks of aging and identifying key areas of aging susceptibility and micro-organisms. Accurately detects environmental features.
This study expands the boundaries of the science of aging and opens new avenues for delaying aging and preventing related diseases.
–IANS
MKS/CBT
