The drug mainly inhibits the PCSK9 protein produced in the liver.
This protein helps in the synthesis of cholesterol.
High Cholesterol New Treatment: Cholesterol is an important fat in our body. It is also called lipid. There are many types of cholesterol. Everyone has their own different work. Cholesterol mainly forms cell membranes, many types of hormones and vitamin D in the body. Cholesterol is formed in the body in two ways. One is produced by food and the other by the liver itself. You will be surprised to know that as much as cholesterol is important for our body, if it starts getting produced in excess then it is equally harmful for us. Low density cholesterol i.e. LDL is a very dangerous cholesterol.
If it exceeds 100 mg per deci liter in our blood then it becomes a threat to life. The problem is that when its quantity increases, it is not even detected. That’s why most people remain ignorant of this matter. Its result suddenly appears in the form of heart attack or stroke.
what kind of medicine is it
When LDL cholesterol becomes high, it starts reaching the blood arteries due to which blood does not reach the heart properly. The medicine currently available does not reduce cholesterol but prevents it from increasing further. But now the trial of a new medicine is going on in KEM Hospital, Mumbai. The name of this medicine is Inclisiran. Its results in trials have been very positive. This medicine is being claimed to eliminate cholesterol. After the trial, this medicine is soon going to get approval from DCGI (Drug controller general of India). It is in the form of injections which are given twice a year and their cost ranges from Rs 2.5 to 3 lakh.
How does this injection work?
Dr. Nityanand Tripathi, Head of Cardiology Department at Fortis Hospital, New Delhi, said that the trial of Inclisiran is going on and its results have been very good. This is the chef. Dr. Nityanand Tripathi told that we have medicines even before Inlisiran. One medicine is Ripatha. But this injection is taken twice a month. These medicines reduce LDL by 50 percent. Obviously, after this the risk of heart disease will also reduce. He told that this medicine mainly inhibits the PCSK9 protein produced in the liver from progressing. PCSK9 protein increases the synthesis of LDL cholesterol. That means this protein is responsible for increasing dirty cholesterol. Inlisiran blocks the PCSK9 protein pathway, which stops cholesterol formation. He told that if the increased cholesterol is reduced by 1 mg then the risk of heart disease reduces by 2 percent.
For whom will this injection be a panacea?
Dr. Nityanand Tripathi told that when someone has excess bad cholesterol then it is very difficult to reduce it. Currently, cholesterol is stopped from progressing with the available medicines. This means that cholesterol will not be produced more than what is there. But for those people who have very high bad cholesterol, this medicine is also not that effective because their cholesterol level is already very high. In such a situation, Inlisiran can prove to be very beneficial. Because with this injection cholesterol can be reduced by 50 percent. This medicine will prove to be very beneficial for people whose cholesterol levels are genetically increased or who have a family history of heart disease. If their cholesterol is above the danger mark, then this medicine will prove to be very beneficial for them.
How big a problem is price?
Such medicines are being given in Britain and America. But there its price is around Rs 5 lakh. But the price of the injection which is going on trial in India is said to be half of this. However, till now no one knows about its actual price. This will be known after the approval of DCGI but it is believed that the cost of one injection will be between 1.25 lakh to 1.5 lakh. Dr. Nityanand Tripathi told that when a new medicine comes, its price always remains high. Since it has been made with the help of special research and technology, its price will definitely be high. But as time passes and research progresses, this medicine becomes cheaper. However, this medicine is given only to certain types of patients.
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Tags: health, Lifestyle
FIRST PUBLISHED: January 10, 2024, 18:20 IST